Table 1.
Estimates of intrinsic clearance (µl min−1 pmol−1 CYP, r2) of tamoxifen to Z-4-OH-tam by supersomes expressing wild-type recombinant CYP450 isoform protein.
Expressed CYP450 isoform | Intrinsic clearance (r2) |
---|---|
CYP2B6 | 2.91×10−2 (0.998) |
CYP2C9 | 3.71×10−2 (0.992) |
CYP2C19 | 3.93×10−2 (0.999) |
CYP2D6 | 4.20×10−2 (0.991) |