Table 3.

Rates of formation (V, pmol mg⁻¹ protein min⁻¹) of Z-4-OH-tam from 10 µm tamoxifen (1% dimethyl sulfoxide) and CYP expression (pmol mg⁻¹ protein) in human liver microsomes from patients with varying CYP2B6 (a), CYP2D6 (b) and CYP2C9 (c) genotypes. Data are mean±s.d. (CI).

a
CYP2B6 variant alleles	V (pmol mg−1 protein min−1)	CYP2B6 expression
zero (n = 18)	9.44±5.47 (6.72–12.2)	26.3±18.6 (17.1–35.6)a,b
one (n = 20)	8.83±6.08 (6.06–11.6)	15.4±19.2 (6.67–24.1)
two (n = 10)	6.82±3.76 (4.13–9.51)	8.77±5.88 (4.56–13.0)

b
CYP2D6 functional alleles	V (pmol mg−1 protein min−1)	CYP2D6 expression
two (n = 26)	9.93±5.43 (7.74–12.1)c	10.4±7.08 (7.51–13.4)d
one (n = 18)	8.10±5.48 (5.38–10.8)	6.45±4.82 (4.05–8.84)e
zero (n = 4)	5.04±3.17 (−0.002–10.1)	0.155±0.161 (−0.1–0.4)

c			CYP2C9 variant alleles	V (pmol mg−1 protein min−1)	CYP2C9 expression
zero: CYP2C9*1/*1 (n = 26)	9.98±6.67 (7.29–12.7)	123±52.0 (102–144)
one: CYP2C9*1/*2 or *1/*3 (n = 19)	7.81±2.69 (6.51–9.10)	111±39.6 (91.8–130)
two: CYP2C9*2/*2 or *2/*3 (n = 4)	5.12±3.93 (−1.13–11.4)	94.9±66.1 (−10.3–200)

^aP<0.05 vs one variant allele

^bP<0.05 vs two variant alleles

^cP<0.05 vs zero functional alleles

^dP<0.001 vs zero functional alleles

^eP<0.05 vs zero functional alleles.