Table 1.

Population distribution of albendazole metabolites in CSF of patients with neurocysticercosis (n=12; one CSF sample was collected from each patient at different time points during the dose interval).

	AUC(0,12 h) (ng ml−1 h)	Cmax (h)	tmax (h)	t1/2d (h)	Kd (h−1)	t1/2 (h)	Kel (h−1)
(+)-ASOX	1836.13	385.5	2.0	2.0	0.347	2.5	0.277
(−)-ASOX	536.55	88.2	2.0	>1.9	0.365	2.5	0.277
ASON	116.11	22.2	2.0	1.6	0.433	2.6	0.267

AUC, area under the CSF concentration-time curve; C_max, maximum CSF concentration; t_max, time to reach C_max; t_1/2d, CSF distribution half-life; K_d, CSF distribution rate constant; t_1/2, CSF elimination half-life; K_el CSF elimination rate constant.