Table 2.
The pharmacokinetics of oral midazolam before and after treatment with grapefruit juice. CI confidence interval.
| Water (CI) | GFJ (CI) | P value | |
|---|---|---|---|
| Midazolam | |||
| AUC (ng ml−1 min) | 24 700 (24 400, 25 000) | 57 100 (55 300, 58 900) | P<0.05 |
| Cmax (ng ml−1) | 87 (31–144) | 101 (32, 170) | NS |
| tmax (min) | 85 (39–130) | 105 (57, 153) | NS |
| t½ (min) | 266 (180–351) | 266 (175, 358) | NS |
| α-hydroxymidazolam | |||
| AUC (ng ml−1 min) | 18 000 (17 600, 18 400) | 6900 (6700, 7200) | P<0.05 |
| Cmax (ng ml−1) | 51 (21, 81) | 14 (6, 22) | P<0.05 |
| tmax (min) | 85 (57, 131) | 147 (87, 208) | NS |
| t½ (min) | 231 (160, 302) | 244 (191, 296) | NS |
| Ratio α-hydroxymidazolam/midazolam AUC | 0.77 (0.46, 1.07) | 0.11 (0.05, 0.19) | P<0.05 |