Table 1.
Effect of selective CYP inhibitors on the metabolism of zaltoprofen in human liver microsomes.
| Inhibitor | µmol l-1 | % of control |
|---|---|---|
| a-Naphthoflavone (CYP1A2) | 0.04 | 97.9 ± 3.9 |
| 0.2 | 98.3 ± 2.2 | |
| 1 | 96.1 ± 4.0 | |
| Tranylcypromine (CYP2A6) | 0.08 | 99.9 ± 1.7 |
| 0.4 | 98.2 ± 2.9 | |
| 2 | 97.9 ± 1.3 | |
| Sulfaphenazole (CYP2C9) | 0.2 | 72.7 ± 1.6 |
| 1 | 33.1 ± 1.1 | |
| 5 | 14.6 ± 2.7 | |
| Oumeprazole (CYP2C19) | 0.4 | 96.3 ± 3.5 |
| 2 | 94.3 ± 1.5 | |
| 10 | 86.5 ± 2.5 | |
| Quinidine (CYP2D6) | 0.04 | 95.7 ± 4.4 |
| 0.2 | 94.5 ± 0.4 | |
| 1 | 95.5 ± 2.4 | |
| Diethyldithiocarbamate (CYP2E1) | 1 | 94.6 ± 2.1 |
| 5 | 94.0 ± 1.9 | |
| 25 | 83.5 ± 1.7 | |
| Ketoconazole (CYP3A4) | 0.04 | 92.5 ± 3.9 |
| 0.2 | 92.7 ± 0.3 | |
| 1 | 91.1 ± 1.4 |
The values are mean ± s.d. (n = 3).