Table 2.

Pharmacokinetic parameters for urinary excretion of formoterol enantiomers and their glucuronide conjugates following an oral dose of rac-formoterol (60 µg formoterol fumarate dihydrate). (Data are median and range for six male volunteers).

	(R; R)-formoterol		(S; S)-formoterol		(R; R)-glucuronide		(S; S)-glucuronide
	Median	Range	Median	Range	Median	Range	Median	Range
ERmax (nmol h−1)	0.74	0.35–1.26	1.36	0.94–2.12	12.5	4.53–18.1	4.85	1.66–9.44
tmaxR (h)	1.5	0.5–2.5	1.5	0.5–2.5	1.5	0.5–2.5	1.5	0.5–2.5
t1/2(2,8 h) (h)	2.9	1.0–5.8	2.7	1.1–3.2	1.2	0.9–1.7	1.4	0.8–2.4
Ae (0–8 h) (% of dose)	2.07	0.97–2.89	3.49	2.56–3.76	21.0	13.1–31.0	10.3	4.23–14.6