Table 1.
Pharmacokinetic parameters for TF-505 following single administration.
| Dose (mg) | Cmax(µg ml−1) | tmax(h) | τ1/2 (h) | AUC(0,72 h) (µg ml−1h) | AUC(0,∞) (µg ml−1h) | MRT (h) | V/F (λ) | CL/F(l h−1) |
|---|---|---|---|---|---|---|---|---|
| 25 | 1.10 ± 0.38 | 4.38 ± 1.01 | 17.50 ± 3.81 | 32.12 ± 14.46 | 34.68 ± 16.39 | 26.19 ± 5.70 | 22.96 ± 10.02 | 0.98 ± 0.57 |
| 50 | 2.45 ± 0.70 | 5.47 ± 2.34 | 20.34 ± 5.03 | 76.95 ± 15.96 | 85.44 ± 20.25 | 30.40 ± 7.32 | 19.35 ± 4.61 | 0.67 ± 0.15 |
| 50 (non fasting) | 2.44 ± 0.32 | 5.87 ± 0.94 | 19.84 ± 2.78 | 79.30 ± 16.22 | 87.02 ± 19.13 | 29.63 ± 4.10 | 18.38 ± 2.39 | 0.66 ± 0.16 |
| 75 | 3.79 ± 1.92 | 4.23 ± 0.86 | 22.74 ± 3.51 | 97.50 ± 46.82 | 101.15 ± 49.01 | 15.79 ± 4.30 | 21.02 ± 30.02 | 1.21 ± 1.24 |
| 100 | 3.12 ± 1.20 | 3.85 ± 0.73 | 24.15 ± 9.20 | 73.22 ± 26.74 | 76.17 ± 28.65 | 15.55 ± 4.93 | 19.88 ± 6.38 | 1.50 ± 0.48 |
Data represent the mean ± s.d. values, n = 6.