Skip to main content
. 2002 Sep;54(3):283–294. doi: 10.1046/j.1365-2125.2002.01656.x

Table 3.

Estimated pharmacodynamic parameters describing the suppressant effect on plasma DHT concentration by TF-505 after single doses 25–100mg.

Dose (mg) kin (% h-1) CV (%) kout (h-1) CV (%) Ic50 (µg ml-1) CV (%)
 25 17.82 27.59 0.17 27.01 0.82 24.66
 50 17.38 22.01 0.16 20.73 1.48 19.78
 75 17.03 23.09 0.17 22.23 1.31 21.00
100 10.70 17.88 0.10 16.30 0.88 21.73

kin, zero-order rate constant for appearance of suppressant effect on plasma DHT concentration; kout, first-order rate constant for disappearance of suppressant effect on plasma DHT concentration; IC50, TF-505 plasma concentration producing half of maximum kin inhibition. Estimates of interindividual variability are expressed as CV, coefficient of variation (%).