Table 4.
Estimates of the effect of dose (in the week before the index day) on the odds ratios (ORs) and their 95% confidence intervals (95% CI) of upper gastrointestinal bleeding.
| Variable | Level (*) | Cases | Controls | OR (95% CI) (†) |
|---|---|---|---|---|
| Paracetamol | < 2000 | 351 | 593 | 1.2 (1.0, 1.4) |
| 2000–3999 | 96 | 150 | 1.2 (0.8, 1.7) | |
| ≥ 4000 | 31 | 42 | 1.0 (0.5, 1.9) | |
| Diclofenac | < 75 | 8 | 15 | 2.2 (0.8, 5.8) |
| 75–149 | 39 | 41 | 3.2 (1.9, 5.5) | |
| ≥ 150 | 27 | 13 | 12.2 (5.6, 26.7) | |
| Ibuprofen | < 1200 | 22 | 58 | 1.1 (0.6, 2.0) |
| 1200–1799 | 18 | 39 | 1.8 (0.8, 3.7) | |
| ≥ 1800 | 6 | 6 | 4.6 (0.9, 22.3) | |
| Indomethacin | ≤ 50 | 9 | 10 | 3.2 (1.1, 9.5) |
| 51–149 | 39 | 21 | 6.8 (3.6, 12.9) | |
| ≥ 150 | 10 | 2 | 20.4 (4.2, 99.7) | |
| Naproxen | < 500 | 6 | 5 | 4.8 (1.3, 18.1) |
| 500–999 | 31 | 24 | 5.4 (2.9, 9.9) | |
| ≥ 1000 | 61 | 17 | 15.6 (8.1, 30.2) | |
| Piroxicam | ≤ 10 | 7 | 3 | 9.0 (2.1, 39.2) |
| 11–20 | 54 | 25 | 12.0 (6.5,22.1) | |
| ≥ 21 | 14 | 1 | 79.0 (9.9, 631.8) |
(*)
All doses in mg day−1.
(†)
All odds ratios are relative to nonuse of any NANSAID or aspirin and are adjusted for use of aspirin, ketoprofen and anticoagulants, smoking, and history of UGI problems.