Table 1.

Demographic profile and baseline LDL-C values of treatment group (Study 1).

	SIM 10 mg + EZE 0.25 mg (n = 11)	SIM 10 mg + EZE 1 mg (n = 12)	SIM 10 mg + EZE 10 mg (n = 12)	SIM 10 mg (n = 12)	Placebo (n = 11)
Age (years)
Mean	36.0	36.1	38.0	34.1	37.1
s.e. mean	1.5	2.3	2.1	2.3	2.8
Median	37	36	41	34	33
Range	28–44	20–47	24–46	21–49	26–50
Baseline weight (kg)
Mean	75.8	73.3	74.8	72.8	72.3
s.e. mean	2.7	3.0	2.6	1.9	2.7
Median	78	71	73	75	68
Range	55–89	55–90	63–97	60–81	62–88
Baseline LDL-C (mg dl−1)
Mean	177.1	177.3	171.4	167.5	164.0
s.e. mean	12.7	12.5	7.3	8.9	6.6
Median	164	174	166	166	161
Range	132–282	130–275	135–219	108a–228	135–203

SIM, simvastatin; EZE, ezetimibe; s.e. mean, standard error; LDL-C, low-density lipoprotein cholesterol.

^aThis subject met the LDL-C entry criterion of ≥130 mg dl⁻¹ at screening.