Table 2.

Risk of first-time acute myocardial infarction associated with current, recent past or past exposure to anti-inflammatory drugs (NSAIDs) stratified by duration of NSAID therapy (expressed as number of prescriptions) and dose.

NSAID use (number of prescriptions)	Cases (n = 3315)	Controls (n = 13139)	Adjusted*odds ratio (95% CI)
Non-users	1502	6236	1.0 (Referent)
Current NSAIDs	242	825	1.17 (0.99–1.37)
1–4	34	111	1.30 (0.87–1.93)
5–9	45	157	1.10 (0.78–1.54)
10–19	36	145	0.97 (0.66–1.42)
20–29	38	119	1.31 (0.89–1.91)
30 +	89	293	1.21 (0.94–1.55)
Recent past NSAIDs	118	377	1.26 (1.01–1.57)
1–4	25	105	0.95 (0.61–1.48)
5–9	21	95	0.90 (0.55–1.46)
10–19	23	77	1.13 (0.70–1.83)
20–29	14	44	1.33 (0.72–2.46)
30 +	35	56	2.71 (1.75–4.22)
Past NSAIDs	1453	5701	1.04 (0.96–1.13)
1–4	984	4002	1.02 (0.93–1.12)
5–9	311	1190	1.06 (0.92–1.22)
10–19	91	352	1.00 (0.78–1.28)
20–29	26	82	1.26 (0.80–2.01)
30 +	41	75	2.33 (1.57–3.46)
Current by dose
Low dose†	98	367	1.02 (0.81–1.29)
High dose‡	144	458	1.29 (1.05–1.58)

^*adjusted for smoking status, body mass index, hormone replacement therapy and aspirin

^†low dose (dose per tablet): acemetacin 60mg, diclofenac <100mg, diflunisal 250mg, etodolac 200mg, fenbufen 300mg, fenoprofen 300mg, flurbiprofen 100mg, ibuprofen ≤200mg, indomethacin ≤75mg, ketoprofen 100mg, mefenamic acid 250mg, nabumetone 500mg, naproxen 275mg, piroxicam 10mg, sulindac 100mg, tenoxicam 20mg and tiaprofenic acid 200mg

^‡high dose (dose per tablet): diclofenac 100mg, diflunisal 500mg, etodolac 300mg, fenbufen 450mg, fenoprofen 600mg, flurbiprofen 200mg, ibuprofen >200mg, indomethacin 100mg, ketoprofen 200mg, mefenamic acid 500mg, nabumetone 500mg, naproxen 500mg, piroxicam 20mg, and tiaprofenic acid 300mg