Table 2.

The formation rate (nmol min⁻¹ mg⁻¹ protein) of OH-celecoxib at 1 and 20 µm celecoxib concentration in human liver microsomes, as well as total spectral P450 (pmol mg⁻¹ protein) and apoprotein content in arbitrary units. n = number of individual liver samples, data expressed as mean ± s.d., §P < 0.05 compared with 2C9 *1/ *1, #P < 0.01 compared with 2C9 *1/ *2.

		Formation rate of OH-celecoxib
Genotype	n	1 µm celecoxib	20 µm celecoxib	Total P 450	CYP2C9 apoprotein
CYP2C9*1/*1	14	0.033 ± 0.012	0.26 ± 0.089	399 ± 201	7.2 ± 4.6
CYP2C9*1/*2	6	0.030 ± 0.015	0.24 ± 0.070	454 ± 99	6.9 ± 3.3
CYP2C9*1/*3	8	0.0150 ± 0065§#	0.15 ± 0.14§	255 ± 105	4.8 ± 2.5
CYP2C9*2/*3	2	0.037; 0.016	0.30; 0.18	594 ± 71	6.3; 5.3
CYP2C9*2/*2	4	0.021 ± 0.011	0.16 ± 0.12	515 ± 356	4.1 ± 0.7
CYP2C9*3/*3	1	0.0061	0.079	516	3.1