Table 2.

Possible pharmacokinetic and pharmacodynamic interactions with SJW.

Drug	Possible mechanism of action
Pharmacokinetic interactions
Warfarin and phenprocoumon	Induction of CYP2C9
Cyclosporin	Induction of CYP3A4 and the transport protein P-glycoprotein
Oral contraceptives	Induction of CYP1A2 and CYP3A4
Theophylline	Induction of CYP1A2
Digoxin	Induction of transport protein P-glycoprotein
HIV protease inhibitors	Induction of CYP3A4
HIV non-nucleoside reverse transcriptase inhibitors	Induction of CYP3A4
Anticonvulsants (carbamazepine, phenobarbitone and phenytoin)	Induction of CYP3A4
Pharmacodynamic interactions
SSRIs	Potentiation of serotonin concentrations
Triptans	Potentiation of serotonin concentrations