Table 4.
The mean log urinary caffeine metabolic ratio (AFMU + 1 U + 1X)/1,7 U (MRc), s.d. and 95% confidence interval (CI) are shown stratified according to CYP1A2 genotype, smoking status and caffeine intake (n = number of subjects).
| Genotype | Smoking status | Caffeine intake | Mean log MRc ± s.d. | 95%CI | n |
|---|---|---|---|---|---|
| *1 A/*1 A | Non-smokers | Low | 0.76 ± 0.32 | (0.66, 0.86) | 39 |
| Smokers | Low | 0.81 ± 0.39 | (0.54, 1.08) | 8 | |
| Non-smokers | High | 0.61 ± 0.25 | (0.50, 0.72) | 19 | |
| Smokers | High | 0.66 ± 0.30 | (0.47, 0.85) | 10 | |
| *1 A/*1F | Non-smokers | Low | 0.79 ± 0.34 | (0.74, 0.84) | 188 |
| Smokers | Low | 0.98 ± 0.33 | (0.82, 1.14) | 16 | |
| Non-smokers | High | 0.69 ± 0.30 | (0.64, 0.74) | 119 | |
| Smokers | High | 0.82 ± 0.34 | (0.73, 0.91) | 51 | |
| *1F/*1F | Non-smokers | Low | 0.81 ± 0.34 | (0.77, 0.85) | 237 |
| Smokers | Low | 0.80 ± 0.27 | (0.69, 0.91) | 22 | |
| Non-smokers | High | 0.68 ± 0.38 | (0.62, 0.74) | 138 | |
| Smokers | High | 0.78 ± 0.30 | (0.70, 0.86) | 57 |