. 2002 Nov;54(5):453–462. doi: 10.1046/j.1365-2125.2002.01676.x

Table 4.

Pharmacokinetic parameters of unchanged drug after oral multiple administration of JTE-522.

	C_{4 h} (ng ml⁻¹)	C_{24 h} (ng ml⁻¹)	t_1/2 (h)	AUC(µg ml⁻¹ h)
Plasma
Day 1	334.2 ± 83.1	93.0 ± 10.9	11.09 ± 3.17#	4.5 ± 0.8^*
	(247.0, 421.4)	(81.6, 104.5)	(7.76, 14.42)	(3.7, 5.3)
Day 2	947.0 ± 261.3	78.4 ± 18.4
	(672.7, 1221.2)	(59.1, 97.7)
Day 3	787.1 ± 260.0	67.4 ± 20.5
	(514.3, 1060.0)	(45.9, 88.9)
Day 4	903.8 ± 131.5	65.8 ±16.8	5.43 ± 0.64^#	8.0 ± 1.6^*
	(765.9, 1041.8)	(48.2, 83.4)	(4.75, 6.10)	(6.3, 9.7)
Day 5	675.8 ± 314.8	71.6 ± 16.6
	(345.4, 1006.2)	(54.2, 89.0)
Day 6	793.0 ± 237.1	69.7 ± 12.4
	(544.2, 1041.8)	(56.7, 82.7)
Day 7	1045.9 ± 193.9	60.9 ± 16.4	5.08 ± 0.73^#	8.5 ± 1.4^*
	(842.4, 1249.3)	(43.6, 78.1)	(4.31, 5.84)	(7.1, 9.9)
				9.4 ± 1.5^**
				(7.9, 10.9)

	C_{4 h} (mg ml⁻¹)	C_{24 h} (mg ml⁻¹)	t_1/2 (h)	AUC(µg ml⁻¹ h)
Blood
Day 1	20.0 ± 2.2	8.2 ± 1.7	16.14 ± 3.20^#	305.6 ± 34.2^*
	(17.6, 22.3)	(6.4, 9.9)	(12.78, 19.50)	(269.7, 341.5)
Day 2	12.2 ± 2.0	3.9 ± 1.0
	(10.1, 14.3)	(2.8, 4.9)
Day 3	9.4 ± 1.4	3.1 ± 0.9
	(7.9, 10.8)	(2.1, 4.1)
Day 4	9.3 ± 1.2	3.0 ± 0.9	12.48 ± 2.27^#	132.6 ± 25.5^*
	(8.0, 10.6)	(2.0, 4.0)	(10.10, 14.86)	(105.8, 159.4)
Day 5	8.7 ± 1.5	3.2 ± 1.0
	(7.2, 10.3)	(2.2, 4.3)
Day 6	9.4 ± 2.1	3.2 ±1.0
	(7.2, 11.5)	(2.2, 4.2)
Day 7	9.3 ± 2.0	2.9 ± 1.0	12.62 ± 2.93^#	130.6 ± 26.3^*
	(7.2, 11.4)	(1.9, 3.9)	(9.55, 15.70)	(103.0, 158.2)
			42.42 ± 8.49^##	282.9 ± 97.6^**
			(33.51, 51.34)	(180.4, 385.3)

Data represent as mean ± s.d., n = 6 Figures in the parentheses represent the 95% confidence interval.

AUC(0,24 h)

^**

AUC (0,•)

calculated from t_max −24 h

^##

calculated from 48 h to last measured point.