Table 2.
Cotinine/nicotine ratios of the plasma concentration and allele frequencies of CYP2A6 gene in 92 Japanese and 209 Koreans.
| Cotinine/nicotine ratios of the plasma concentration | ||
|---|---|---|
| Genotype | Japanese | Koreans |
| CYP2A6*1 A/CYP2A6*1 A | 4.13 ± 3.00 (n = 22) | 7.42 ± 6.56 (n = 41)** |
| CYP2A6*1 A/CYP2A6*1B | 6.05 ± 3.99 (n = 14) | 10.34 ± 16.89 (n = 79)* |
| CYP2A6*1 A or CYP2A6*1B | (n = 0) | 12.54 (n = 1) |
| /CYP2A6*1 × 2 | ||
| CYP2A6*1B/CYP2A6*1B | 4.94 ± 3.49 (n = 12) | 12.53 ± 9.70 (n = 27)* |
| CYP2A6*1 A/CYP2A6*4 | 2.55 ± 1.22 (n = 15) | 4.79 ± 3.17 (n = 19)* |
| CYP2A6*1B/CYP2A6*4 | 4.49 ± 2.66 (n = 10) | 8.10 ± 4.85 (n = 16)* |
| CYP2A6*4/CYP2A6*4 | 0.00 ± 0.00 (n = 3) | 0.00 ± 0.00 (n = 4)* |
| CYP2A6*1 A/CYP2A6*5 | (n = 0) | 5.68 (n = 1) |
| CYP2A6*1B/CYP2A6*5 | (n = 0) | 14.82 (n = 1) |
| CYP2A6*1 A/CYP2A6*7 | 1.47 ± 0.92 (n = 3) | 6.27 ± 4.76 (n = 7)* |
| CYP2A6*1B/CYP2A6*7 | 3.74 (n = 1) | 13.35 (n = 1) |
| CYP2A6*7/CYP2A6*7 | 1.10 (n = 1) | 0.92 (n = 2) |
| CYP2A6*7/CYP2A6*4 | 0.79 ± 0.62 (n = 5) | 2.08 (n = 2) |
| CYP2A6*1 A/CYP2A6*8 | 3.37 (n = 2) | 4.52 ± 2.95 (n = 3) |
| CYP2A6*1B/CYP2A6*8 | 4.35 (n = 2) | 10.33 ± 8.81 (n = 3) |
| CYP2A6*7/CYP2A6*10 | 0.73 (n = 1) | 1.75 (n = 1) |
| CYP2A6*10/CYP2A6*4 | 0.09 (n = 1) | 0.07 (n = 1) |
| Total | 3.78 ± 3.09 (n = 92) | 8.73 ± 11.88 (n = 209)** |
| Number of alleles (%) | ||
|---|---|---|
| Allele | Japanese (n = 184) | Koreans (n = 418) |
| CYP2A6*1 A | 78 (42.4) | 192 (45.9) |
| CYP2A6*1B | 51 (27.7) | 155 (37.1) |
| CYP2A6*2 | 0 (0) | 0 (0) |
| CYP2A6*3 | 0 (0) | 0 (0) |
| CYP2A6*4 | 37 (20.1) | 46 (11.0) |
| CYP2A6*5 | 0 (0) | 2 (0.5) |
| CYP2A6*6 | 0 (0) | 0 (0) |
| CYP2A6*7 | 12 (6.5) | 15 (3.6) |
| CYP2A6*8 | 4 (2.2) | 6 (1.4) |
| CYP2A6*10 | 2 (1.1) | 2 (0.5) |
Data are expressed as mean ± s.d.
*
P < 0.05
**
P < 0.005, from Japanese subjects with each genotype by Mann–Whitney U-test.