Table 2.
Summary of plasma and urine mevalonic acid parameters after morning and evening administration of rosuvastatin.
| Parameters (units) | Morning | Evening n = 21 | 90% CIan = 21 |
|---|---|---|---|
| Trough plasma concentration (ng ml−1) | |||
| Mean baseline | 2.88 | 2.90 | NA |
| Mean day 14 | 1.45 | 1.54 | NA |
| Peak plasma concentration (ng ml−1) | |||
| Mean baseline | 7.55 | 7.53 | NA |
| Mean day 14 | 5.26 | 4.90 | NA |
| Mean percentage change | −25.9 | −31.0 | NA |
| Plasma AUC(0,24 h) (ng ml−1 h) | |||
| Mean baseline | 117 | 116 | NA |
| Mean day 14 | 79.1 | 72.9 | NA |
| Mean percentage change | −29.9 | −32.6 | −3.47, 8.10 |
| Daily urine excretion (µg) | |||
| Mean baseline | 197 | 240 | NA |
| Mean day 14 | 130 | 133 | NA |
| Mean ratio (day 14/baseline) | 0.664 | 0.708 | NA |
| Mean percentage change | −33.6 | −29.2 | −12.76, 3.81 |
CI – confidence interval. NA – not applicable.
a
90% CI for difference of morning-evening least square geometric means.