Table 3.

Summary of pharmacokinetic parameters for rosuvastatin after morning and evening administration of rosuvastatin.

Parameter (units)	Morning n = 21	Evening n = 21	Treatment effecta (90% CI)
Cmax (ng ml−1)	4.58b	4.54b	1.01 (0.88–1.15)
tmax (h)	3.0c	3.0c	NA
AUC(0,24 h) (ng ml−1 h)	40.1b	42.7b	0.94 (0.86–1.03)
AUC(0,∞) (ng ml−1 h)	71.8bd	76.4bd	0.96 (0.84–1.11)e
t1/2 (h)	31.3fd	26.5fd	5.89 (0.91–10.88)e

AUC(0,∞) – area under the plasma concentration-time curve from time zero to infinity. AUC(0,24 h) – area under the plasma concentration-time curve from time zero to 24 h. C_max – peak plasma concentration. CI – confidence interval. LSM – least squares mean. NA – not applicable. t_1/2 – plasma terminal elimination half-life. t_max– time to C_max.

^aTreatment effect = ratio of morning/evening least square geometric means (except for t_1/2: difference of morning-evening least square geometric means).

^bGeometric mean.

^cMedian.

^dn = 16.

^en = 14.

^fArithmetic mean.