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Effect of phosphate buffer (pH 7.4) concentration on the rate of AZT glucuronidation by pooled human liver microsomes. Native (▴) refers to native microsomes, and Activated (▪) to Brij58 treated microsomes (0.15 w/w). Incubations contained AZT (1 mm), UDPGA (10 mm) and MgCl2 (4 mm).
