Table 2.

Predicted zidovudine glucuronidation hepatic clearances derived from the well-stirred, parallel tube and dispersion models^a.

	Predicted CLH(l h−1)
Microsome treatment	Well-stirred	Parallel tube	Dispersion
Native,	3.61 ± 1.38	3.70 ± 1.44	3.67 ± 1.42
phosphate-buffered	(1.90, 5.32)	(1.91, 5.48)	(1.90, 5.43)
Native, Tris-buffered	4.69 ± 0.96	4.82 ± 1.01	4.78 ± 1.00
	(3.50, 5.88)	(3.56, 6.07)	(3.54, 6.02)
Activated (Brij58),	11.27 ± 4.06*	12.24 ± 4.37*	11.98 ± 4.26*
phosphate-buffered	(6.53, 16.34)	(6.81, 16.66)	(6.69, 16.47)
Activated (Brij58),	11.88 ± 2.00*	12.71 ± 2.29*	12.46 ± 2.20*
Tris-buffered	(9.54, 15.20)	(9.86, 15.59)	(9.65, 15.36)

^aData presented as mean ± s.d., with 95% confidence intervals in parenthesis, for microsomes from 5 human livers.

^*P < 0.05 compared with values for phosphate- and Tris-buffered native microsomes.