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Kinetic data for zidovudine glucuronidation by native and detergent activated pooled human liver microsomes in phosphate buffer of concentration 0.02 m.
| Microsome treatment | Km (µm) | Vmax (pmol min−1 mg−1) | CLint (µl min−1 mg−1) |
|---|---|---|---|
| Native, phosphate buffer 0.1 m | 890 | 957 | 1.08 |
| Native, phosphate buffer 0.02 m | 551 | 999 | 1.81 |
| Activated (Brij58), phosphate buffer 0.1 m | 1018 | 3708 | 3.64 |
| Activated (Brij58), phosphate buffer 0.02 m | 672 | 3960 | 5.89 |
