Table 1.
Mean ± s.e. mean (95% confidence interval) concentrations of 8-MOP in epidermis (section 1–5) and dermis (section 6–12).
| 8-MOP concentrations | 8-MOP administration | ||
|---|---|---|---|
| (pg mm−3) | Cream | Bath | Oral |
| Epidermis (Time 1) | 128.0 ± 22.6* | 56.7 ± 25.3 | 27.0 ± 25.3 |
| (77.6, 178.4) | (0.4, 113.1) | (−29.3, 83.3) | |
| Dermis (Time 1) | 7.1 ± 2.8* | 8.8 ± 3.1* | 20.0 ± 3.1 |
| (0.9, 13.3) | (1.8, 15.7) | (13.1, 27.0) | |
| Epidermis (Time 2) | 58.2 ± 11.5 | 39.6 ± 12.9 | 30.0 ± 12.9 |
| (32.4, 83.9) | (10.8, 68.3) | (1.8, 58.8) | |
| Dermis (Time 2) | 8.4 ± 2.0* | 7.7 ± 2.2* | 16.2 ± 2.2 |
| (4.0, 12.8) | (2.8, 12.6) | (11.2, 21.1) | |
| Epidermis (Time 3) | 58.6 ± 8.4 | 42.4 ± 9.4 | 28.5 ± 9.4 |
| (39.8, 77.4) | (21.4, 63.5) | (7.5, 49.6) | |
| Dermis (Time 3) | 1 5.8 ± 2.6 | 8.1 ± 2.9 | 12.9 ± 2.9 |
| (10.1, 21.7) | (1.6, 14.5) | (6.5, 19.3) | |
Time 1: directly after cream or bath application time or 1 h after oral administration. Time 2: 0.5 h after the end of cream or bath, 2 h after oral administration. Time 3: 1 h after the end of cream or bath, 3 h after oral administration.
*
Statistically significant mean difference vs oral administration with P < 0.05.