Table 1.
Population pharmacokinetic parameters of E7070.
| Total data set (n = 75) Estimate (CV%) | Index data set (n = 37) Estimate (CV%) | Validation data set (n = 38) Estimate (CV%) | |
|---|---|---|---|
| Parameter | |||
| V (l) | 6.3 (3.8) | 6.4 (5.2) | 6.3 (5.4) |
| Dmax (mg h−1) | 41 (16) | 47 (21) | 31 (30) |
| Dm (mg l−1) | 3.9 (16) | 4.3 (18) | 2.7 (40) |
| K21 (h−1) | 0.12 (14) | 0.11 (19) | 0.10 (20) |
| K13 (h−1) | 1.1 (7.3) | 1.1 (11) | 1.0 (9.9) |
| K31 (h−1) | 0.51 (7.5) | 0.57 (11) | 0.44 (11) |
| Km (mg l−1) | 0.52 (20) | 0.75 (23) | 0.31 (30) |
| Vmax (mg h−1) | 3.1 (12) | 4.2 (6.4) | 2.7 (17) |
| K10 (h−1) | 0.036 (16) | 0.029 (22) | 0.037 (16) |
| Interindividual variability (%) | |||
| V | 26 (18) | 24 (29) | 27 (24) |
| Dmax | 37 (56) | 39 (62) | 35 (81) |
| Dm | 100 (38) | 130 (38) | 88 (56) |
| K21 | 60 (25) | 56 (24) | 59 (56) |
| K13 | 26 (36) | 26 (58) | 21 (47) |
| Vmax | 48 (40) | 56 (65) | 44 (57) |
| K10 | 62 (42) | 65 (57) | 49 (57) |
| Residual variability | |||
| Proportional error (%) | 15 (6.1) | 13 (9.8) | 15 (6.7) |
| Additive error (mg l−1) | 0.021 (17) | 0.015 (29) | 0.021 (20) |
CV = coefficient of variation.