Table 2.
Pharmacokinetic parameters of quinine disposition, protein-binding of quinine and metabolism of quinine in control subjects and haemodialysis patients
| Controls | Haemodialysis | Pvalue | |
|---|---|---|---|
| Quinine disposition | |||
| Cmax (µg ml−1) | 2.60 ± 0.99 | 4.56 ± 1.58 | 0.004 |
| CLo (ml min−1 kg−1) | 2.51 ± 1.59 | 1.41 ± 0.63 | 0.033 |
| Vd area (l kg−1) | 1.43 ± 0.78 | 0.95 ± 0.29 | 0.080 |
| Kel (h−1) | 0.106 ± 0.031 | 0.090 ± 0.023 | 0.221 |
| t1/2 (h) | 7.02 ± 1.72 | 8.26 ± 2.10 | 0.382 |
| Protein-binding of quinine | |||
| Free fraction | 0.063 ± 0.014 | 0.024 ± 0.015 | 0.001 |
| (Bound/Free) AAG (l g−1) | 26.0 ± 6.0 | 31.0 ± 13.4 | 0.191 |
| (Bound/Free) albumin (l g−1) | 0.4 ± 0.1 | 1.6 ± 0.4 | 0.001 |
| Free CLo (ml min−1 kg−1) | 41.1 ± 24.0 | 67.9 ± 32.0 | 0.033 |
| Metabolism of quinine | |||
| Free fraction | 0.063 ± .014 | 0.024 ± .015 | 0.001 |
| AUC free quinine | 2.11 ± 1.04 | 1.40 ± .55 | 0.080 |
| AUC3-OH-Q | 12.9 ± 4.3 | 45.1 ± 51.3 | 0.083 |
| AUC10−11-Q | 2.42 ± 0.89 | 4.46 ± 1.07 | 0.003 |
| Ratio 3-OH-Q/free quinine | 6.80 ± 2.12 | 46.30 ± 74.38 | 0.049 |
| Ratio 10–11-Q/free quinine | 1.36 ± .66 | 4.12 ± 3.04 | 0.002 |
Data are presented as mean ± s.d.