Table 2.

Pharmacokinetic parameters (mean±s.e. mean) for continuously or intermittently administered dofetilide for 24 days.

	Study treatment day
	1	5	10	17	24
Cmax (ng ml−1)
Cont	4.79 ± 0.27	7.10 ± 0.54	6.93 ± 0.47	7.08 ± 0.51	6.99 ± 0.35
Int	4.61 ± 0.34	4.74 ± 0.48	4.48 ± 0.40	4.69 ± 0.40*	5.01 ± 0.39
tmax (h)
Cont	3.13 ± 0.23	1.94 ± 0.33	2.31 ± 0.21	2.13 ± 0.28	2.38 ± 0.36
Int	2.81 ± 0.33	2.56 ± 0.35	2.56 ± 0.29	2.50 ± 0.38*	2.69 ± 0.21
AUC(0, 12 h) (ng ml−1 h)
Cont	31.82 ± 1.51	47.30 ± 1.80	47.54 ± 1.82	48.52 ± 2.77	48.60 ± 2.69
Int	32.23 ± 2.35	31.59 ± 2.21	32.05 ± 1.82	31.70 ± 2.54*	33.17 ± 2.33

All values n = 8 except (n = 7).

Cont = continuously; Int = intermittently.