Table 2.
Distribution of patient characteristics and lipid-lowering drug exposure among all case and control patients and their association with VTE risk in multivariate analysis.
| Case (n = 72) | Control (n = 432)* | Unadjusted odds ratio (95% CI) | Adjusted odds ratio (95% CI) | |
|---|---|---|---|---|
| Age (years) | ||||
| 40–49 | 10 (13.9%) | 56 (13.0%) | – | – |
| 50–59 | 23 (31.9%) | 140 (32.4%) | – | – |
| 60–69 | 23 (31.9%) | 150 (34.7%) | – | – |
| 70–79 | 16 (22.2%) | 86 (19.9%) | – | – |
| Sex | ||||
| ;Male | 36 (50.0%) | 216 (50.0%) | – | – |
| Female | 36 (50.0%) | 216 (50.0%) | – | – |
| Smoking | ||||
| Nonsmoker | 41 (56.9%) | 221 (51.2%) | – | – |
| Current | 17 (23.6%) | 71 (16.4%) | 1.4 (0.7, 2.7) | 2.0 (1.0, 4.4) |
| Ex-smoker | 6 (8.3%) | 70 (16.2%) | 0.4 (0.2, 1.1) | 0.4 (0.2, 1.1) |
| Unknown | 8 (11.1%) | 70 (16.2%) | 0.6 (0.2, 1.3) | 1.2 (0.4, 3.8) |
| Body mass index (kg/m2) | ||||
| < 25.0 | 19 (26.4%) | 123 (28.5%) | – | – |
| 25.0–29.9 | 25 (34.7%) | 130 (30.1%) | 1.2 (0.6, 2.3) | 1.9 (0.9, 3.7) |
| ≥ 30.0 | 17 (23.6%) | 65 (15.1%) | 1.7 (0.8, 3.6) | 2.5 (1.1, 5.7) |
| Unknown | 11 (15.3%) | 114 (26.4%) | 0.6 (0.3, 1.3) | 0.6 (0.2, 1.7) |
| Oestrogen use | ||||
| None | 52 (72.2%) | 366 (84.7%) | – | – |
| Current | 15 (20.8%) | 40 (9.3%) | 5.3 (2.1, 13.6) | 6.5 (2.4, 17.9) |
| Past | 5 (6.9%) | 26 (6.0%) | 2.3 (0.7, 7.7) | 2.3 (0.7, 7.7) |
| Exposures of interest | ||||
| Normolipidaemic nonuse | 59 (81.9%) | 329 (76.2%) | – | – |
| Current/recent statin use | 3 (4.2%) | 18 (4.2%) | 0.9 (0.3, 3.4) | 1.1 (0.3, 4.3) |
| Past statin use | 2 (2.8%) | 5 (1.2%) | 2.0 (0.3, 11.3) | 3.7 (0.6, 24.1) |
| Current/recent other | 0 (0.0%) | 12 (2.8%) | – | – |
| lipid-lowering drug use | ||||
| Past other lipid-lowering drug use | 2 (2.8%) | 6 (1.4%) | 1.8 (0.3, 9.5) | 2.0 (0.3, 11.6) |
| Mixed use | 0 (0.0%) | 6 (1.4%) | – | – |
| Hyperlipidaemic nonuse | 6 (8.3%) | 56 (13.8%) | 0.6 (0.2, 1.5) | 0.4 (0.2, 1.2) |
Including 355 controls from the same general practice, and 77 controls selected from the other practices.