Table 3.
Polymorphisms identified within the 5′ flanking region of the human β2-adrenoceptor gene. (reproduced with permission from Scott et al. [27]).
| bp upstream from ATG | Base change | Putative regulatory site |
|---|---|---|
| −20 | T→C | – |
| −47 | T→C | Non-conservative amino acid change in 5′ leader peptide (BUP: Cys→Arg) |
| −367 | T→C | Creates 7/8 bases of a consensus AP2 site and is 7 bp 3′ of an overlapping AP2/Sp1 site |
| −468 | C→G | – |
| −654 | G→A | p53 site |
| −1023 | G→A | 2 bp 3′ of an NF-IL6 site |
| −1343 | A→G | – |
| −1429 | T→A | 3 bp 3′ of steroid binding hexamer |