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. 2002 Jan;53(1):49–57. doi: 10.1046/j.0306-5251.2001.01529.x

Table 3.

Pharmacokinetic parameters of diazepam following i.v. and p.r. administration. Values are expressed as mean (95% confidence interval, CI) or

Parameter	i.v.	p.r.
t_{½, λ₁} (h)	0.5 (0.28, 0.73) [n = 11]	–
t_{½, λ_z} (h)	60 (38, 82) [n = 11]	–
V_ss (l kg⁻¹)	3.5 (1.3, 5.7) [n = 11]	–
CL (ml min⁻¹ kg⁻¹)	0.73 (0.4, 1.03) [n = 11]	–
t_max (min)†	5 (5–10) [n = 16] [n = 16]	25 (10–120) [n = 7]
C_max (ng ml⁻¹)†	634 (402–1507) [n = 16]	423 (112–1953) [n = 7]
t > 200 ng ml⁻¹ (min)†	5 (5–5) [n=16]	5 (5–10) [n=9]
AUC(0,12 h) (ng ml⁻¹ h)	2367 (1661, 3073) [n = 5]	4082 (970, 5872) [n = 7]
AUC(12,24 h) (ng ml⁻¹ h)	1717 (1107, 2327) [n = 5]	3247 (623, 5872) [n = 7]
AUC(24,48 h) (ng ml⁻¹ h)	2663 (1090, 4634) [n = 5]	5604 (833, 10 374) [n = 7]