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. 2002 Oct 15;16(20):2684–2698. doi: 10.1101/gad.242002

Figure 4.

Figure 4

Impaired filopodia extension at the leading front of growing microvessel networks in the absence of heparin-binding VEGF-A. (A–H) PECAM-positive microvessels with laterally (arrowheads) and perpendicularly (arrows) extending filopodia in wt/wt (A,C,E,F) and 120/120 (B,D,G,H) hindbrains at 10.75 (A,B) and 11.25 (C–H) dpc; the midline is situated off the left side of the image in A and B and is indicated with a red line in C and D; examples of fusing microvessels are indicated with open arrowheads; examples of dilated or bulbous vessel ends in the 120/120 hindbrains are indicated with stars; examples of abnormally localized perpendicular filopodia in D are circled; and the corresponding region devoid of filopodia in C is indicated with a hash. (E,F) The lateral (E) and perpendicular (F) filopodial extensions in the areas boxed in C, magnified 2.5×. (G,H) The lateral (G) and perpendicular (H) filopodial extensions in the areas boxed in D, magnified 2.5×. Bars: A,B, 10 μm; C,D, 20 μm.