Table 4.

Morphological analysis by μCT of femurs from CD40L KO mice compared with respective WT mice

Morphological parameters	WT mice	CD40L KO mice	% change	P
TV, mm3	1.19 ± 0.05	1.17 ± 0.11	−1.7	≤ .570
BV, mm3	0.29 ± 0.02	0.19 ± 0.029	−34.5	≤ .001*
BV/TV, %	24.37 ± 1.66	16.24 ± 1.67	−33.4	≤ .001*
Tb. Th., μm	67.94 ± 2.99	63.57 ± 3.05	−6.4	≤ .002*
Tb. Sp., μm	230.14 ± 13.49	272.90 ± 18.39	18.6	≤ .001*
Tb. N./mm	4.37 ± 0.19	3.91 ± 0.26	−10.5	≤ .001*
SMI	0.59 ± 0.11	1.11 ± 0.19	88.1	≤ .001*
Conn. D./mm3	90.10 ± 12.97	57.00 ± 8.94	−36.7	≤ .001*
Co. Th., μm	100.6 ± 4.5	94.3 ± 7.2	−6.3	≤ .016*
Co. Vol., μm	0.51 ± 0.03	0.48 ± 0.04	−5.9	≤ .046*

Trabecular indices, including TV, BV, BV/TV, Tb. Th., Tb. Sp., Tb. N., SMI, and Conn. D., and the cortical indices Co. Th. and Co. Vol. were computed from μCT scans of CD40 and CD40L KO mice and their respective WT controls. The data are presented as the mean ± SD. Percentage change between WT and KO mice is indicated as “% change.” Asterisks indicate significantly different results (P ≤ .05); n = 11 mice per group for CD40L KO and WT mice.