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. 2007 Feb 25;35(6):1773–1786. doi: 10.1093/nar/gkm059

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© 2007 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 10. — Model of Sox2, Oct-3/4 and Nanog feedforward and feedback gene regulation. Sox2 is shown as a central node in a network of genes critical to embryogenesis as well as stem cell self-renewal and pluripotency. (A) At normal levels, Sox2 and Oct-3/4 activate transcription of all known Sox2:Oct-3/4 target genes. (B) Increasing levels of Sox2 leads to inhibition of target gene expression. (C) Increasing levels of Oct-3/4 inhibits expression of only Oct-3/4 and Nanog, and high levels of Nanog lead to inhibition of Nanog gene expression, but not other Sox2:Oct-3/4 target genes. Presumably, there are additional Sox2:Oct-3/4 target genes that are regulated in a similar fashion.