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. 2002 Oct 15;16(20):2713–2728. doi: 10.1101/gad.1022402

Figure 3.

Figure 3

spr-1 gene structure and protein product. (A) The relationship between the two previously predicted open reading frames, D1014.8 and D1014.9, to the spr-1 gene structure we determined is shown. spr-1(ar200) affects the splice acceptor at the start of exon 9, resulting in a frameshift that leads to a stop codon. spr-1(ar205) is a G-to-A transition that results in a stop codon in exon 9. (B) SPR-1/CoREST protein family. The domain structure of SPR-1 and of all the mammalian homologs found in the databases is shown. spr-1(ar200) and spr-1(ar205) results in truncation of the SPR-1 protein as shown. The spacing between the ELM2 and the first SANT domain is always 24 amino acids; the spacing between the SANT domains is variable, as indicated. Accession nos.: SPR-1, AAA96286; hCoREST, no. AF155595; mCoREST (murine 1A13), no. X83587; KIAA1343, no. BAA92581. Note that KIAA1343 most likely represents a partial cDNA.