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. 2002 Oct 15;16(20):2713–2728. doi: 10.1101/gad.1022402

Figure 6.

Figure 6

Identification of Y40B1B.6 as spr-5 by RNAi and sequence analysis. (A) RNAi analysis of C. elegans CoREST complex homologs. Double stranded RNA was delivered to sel-12(ar171) unc-1(e538) hermaphrodites by either feeding (hda-1, hda-2, hda-3) or injection (Y40B1B.6, R13G10.2, T08D10.2). At least 60 individuals fed dsRNA were examined: (−) no Egl+ individuals were seen. The progeny of at least 14 injected hermaphrodites were examined: (−) no Egl+ individuals were seen. For Y40B1B.6, 35/37 injected animals gave many Egl+ progeny. (B) The predicted protein structure of Y40B1B.6 and the position of the mutation found in spr-5(ar197) are shown. The overlapping FAD-binding (hatched box) and polyamine oxidase (gray box) domains are indicated.