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. 2002 Oct 15;16(20):2713–2728. doi: 10.1101/gad.1022402

Figure 7.

Figure 7

Models for SPR-1 and SPR-5 function. (A) SPR-1 and SPR-5 are part of a corepressor complex affecting the transcription of known members of the LIN-12/Notch pathway. Although no evidence exists, hop-1 transcription could, for example, be affected in a cell-specific way. Alternatively, the complex could repress the transcription of a subset of crucial genes for π cell fate which would not get activated in lin-12(−) or sel-12(−) mutants unless this repression is released. (B) SPR-1/CoREST and SPR-5/p110b are part of the LAG-1-associated corepressor complex. After ligand binding leads to the presenilin-dependent release of the intracellular domain of LIN-12 (yellow, noted “intra”), the corepressor complex is released and a coactivator complex formed, leading to activation of the target genes. (C) SPR-1 and SPR-5 form a distinct corepressor complex, which may interact with the LAG-1 repressor complex. The corepressor complex containing SPR-1 and SPR-5 is targeted to the DNA by a factor X, and is distinct from the LAG-1 complex. This complex, which can comprise more factors, may cooperate with the LAG-1 complex to potentiate repression. Association of LAG-1 and LIN-12(INTRA) might or might not release the CoREST corepressor complex as well.