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Multidimensional regulation of Th cell differentiation by IL-12 family members plus IL-4. Solid arrows show Th1, Th2, and Th17 differentiation axes induced by IL-12, IL-4, and IL-23, respectively, plus anti-inflammatory axis by IL-27. Dashed arrows show roles of IL-27 and IL-23 for Th1 induction. IL-12 cytokine family members are underlined.
