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. 2002 Nov 1;16(21):2813–2828. doi: 10.1101/gad.1017802

Figure 9.

Figure 9

Expression of markers of chondrocytes, Ihh/Pthrp regulatory signaling molecules, and markers of osteoblast differentiation in Sox9flox/flox; Col2a1–Cre mice. (A) Expression of Col2a1, Aggrecan, and Comp, but not Col10a1 was dramatically down-regulated in E15.5 mutant metacarpals. (B) RNA in situ hybridization showed down-regulation of Pthrp, PPR, Ihh, and Ptc1 in E15.5 mutant metacarpals. (C) Expression in radius of E15.5 mutant mice of Bsp, Osteopontin, Osteocalcin, and Runx2 revealed normal osteoblast differentiation. P, proliferating; PH, prehypertrophic; H, hypertrophic.