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. 2002 Nov 15;16(22):2849–2864. doi: 10.1101/gad.1025702

Figure 5.

Figure 5

Smo−/− cells ectopically express Class I genes in the ventral spinal cord. Sections through the neural tube of control (Smo+/+ or Smo+/−; A,E,I,M,Q) and experimental (Smo−/−; B–D,F–H,J–L,N–P,R–T) chimeras. Normal domains of Dbx1 (A,Q), Dbx2 (E), Irx3 (I), and Pax6 (M,Q) progenitor cells. Smo−/− cells (green in B,F,J,N; blue in R) ectopically activate expression of Dbx1 (C,D), Dbx2 (G,H), Irx3 (K,L), and Pax6 (O,P) in the ventral spinal cord. However, Smo−/− cells fail to express Dbx1 (B–D), Dbx2 (F–H), and Pax6 (N–P,R–T) in their normal domains in the intermediate region of the spinal cord (see text). Panels R, S, and T represent two independent confocal pictures of the intermediate region of the spinal cord of chimeric embryos. Bar, 20 μm.