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. 2002 Dec 1;16(23):3074–3086. doi: 10.1101/gad.242602

Figure 1.

Figure 1

A CD44 variant isoform is required for Met activation. (A) HT29, ASML cells, and primary keratinocytes were each induced with HGF for 5 min in the presence or absence of antibodies (for HT29 cells and keratinocytes, αv6 was BIWA; for ASML cells αv6 was 1.1ASML). Subsequently, Met or Erk phosphorylations were determined (see Materials and Methods). (B) HT29 cells grown in the absence (control) or presence of HGF with or without antibodies directed against CD44v6 (BIWA) were visualized by phase contrast microscopy. Magnification, 40×. (C) Invasion of ASML cells into Matrigel was measured in the absence (control) or presence of HGF with or without antibodies directed against CD44v6 (1.1ASML). Each point represents the average of three independent determinations ±S.D.