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. 2002 Dec 15;16(24):3223–3235. doi: 10.1101/gad.1032702

Figure 6.

Figure 6

Various membrane defects in milk fat droplets from XOR+/− mice. (A–D) TEM analysis of milk fat droplets from XOR+/− mammary glands at lactation day 3. (A) The white arrow points to a bilayer membrane of correctly enveloped fat droplet areas as found in wild-type. The black arrow points to a completely unenveloped droplet. The white arrowhead points to an unidentified membrane structure discussed in the text. (B) Higher-power view of the boxed area in A. (C) Three membrane phenotypes can be found on a single XOR+/− milk fat droplet. The white arrow points to a portion of normal membrane bilayer. The black arrow indicates a piece of cytoplasmic crescent. Another portion of the fat droplet is occupied by the unidentified membrane structure as seen in A and B (white arrowhead). (D) XOR+/− milk fat droplet with a portion of cytoplasmic crescent that is only loosely associated with the droplet. (E) TEM analysis of an entire alveolus in a XOR+/− mammary gland at lactation day 3. The arrows point to completely destroyed mammary epithelial cells. (F) Higher-power view of boxed area in (E). Numerous free-floating mitochondria and ER are seen in burst cells of XOR+/− mammary glands (white arrows). N, nucleus. Magnification: A, 30,000×; B, 70,000×; C,D, 50,000×; E, 1000×; F, 3000×.