Figure 5.

Replacing functional genes with random genes reduces neighbor divergence scores gracefully. We replaced genes in two functional gene groups (“autophagy” and “ion homeostasis”) with random genes, and scores were recalculated for the corrupted groups. Each point represents 10 scores; error bars indicate 95% confidence interval of scores for that many genes replaced. Neighbor divergence scores above .1 are very significant (see Fig. 3). Neighbor divergence scores remain significant despite replacement of about 38% (6 of 16 genes) of the “autophagy” genes and 60% (26 of 43 genes) of the “ion homeostasis” genes.