Table 1.
Progression of neurodegeneration in anti-NGF transgenic mice
| Phenotypic markers | Brain areas | Age, month
|
||
|---|---|---|---|---|
| 1 | 2–3 | 15 | ||
| ChAT reduction | − | + | ++ | |
| Hyperphosphorylated τ | Entorhinal cortex | − | + | ++ |
| Parietal cortex | − | − | ++ | |
| Occipital cortex | − | − | ++ | |
| Hippocampus | − | + | ++ | |
| Tangles | − | − | ++ | |
| Amyloid plaques | − | − | ++ | |
| Retention and transfer test | n.d. | +* | + | |
| DNA fragmentation | Cerebral cortex | − | − | ++ |
| Basal forebrain | − | − | − | |
The analysis was performed on six anti-NGF mice and six transgenic controls with the exception of 1-month-old mice, where the study was performed on three animals per experimental group. n.d., not done. + indicates a qualitative measure of each phenotypic marker.
*
The experiments were performed by using 4-month-old mice.