Table 1.
Mutant Frequencies and Genome Rearrangements in Organs of Young and Old Mice
| Organ | Age (mo) | LacZ mutant frequency (×10−5)a | Genome rearrangements per cellb | Pc | |
|---|---|---|---|---|---|
| total | genome rearrangements | ||||
| Brain | 4 | 3.1 ± 0.3 | 0.5 ± 0.1 | 5 | 0.7333 |
| 32 | 5.0 ± 1.3 | 0.6 ± 0.4 | 6 | ||
| Liver | 4 | 3.1 ± 0.3 | 0.9 ± 0.2 | 9 | 0.0140 |
| 32 | 10.5 ± 2.4 | 2.7 ± 1.0 | 27 | ||
| Heart | 3 | 4.1 ± 1.4 | 1.9 ± 0.8 | 19 | 0.0262 |
| 32 | 10.1 ± 2.7 | 3.7 ± 2.0 | 37 | ||
| Small intestine | 3 | 6.1 ± 1.8 | 1.5 ± 0.5 | 15 | 0.9999 |
| 32 | 19.5 ± 1.0 | 2.4 ± 2.1 | 24 | ||
a
Mean ± SD.
b
Average number of genome rearrangements per diploid genome, based on a 3-kb target locus, a 6 × 106 kb diploid genome, and a twofold chance of a breakpoint falling within a reporter gene.
c
Significance between age groups within organs for genome rearrangements using the Wilcoxon rank sum test.