. 2002 Nov;12(11):1739–1748. doi: 10.1101/gr.334302

Table 1.

Herpesvirus-Human Homologs

Function class	Viral function (VIDA)	HPF¹	Virus²	GenBank³	Human function

DNA replication	DNA polymerase	1	a,b,g	8393995	polymerase (DNA-directed), α
		293	o	15303524	polymerase (DNA directed), δ 1
	helicase/primase	16	a,b,g	5523990	DNA helicase
Nucleotide repair/	uracil–DNA glycosylase	8	a,b,g	6224979	uracil–DNA glycosylase
metabolism	ribonucleotide reduct. large sub.	24	a,b,g	4506749	ribonucleotide reductase M1 polypeptide
	ribonucleotide reduct. small sub.	33	a,g	4557845	ribonucleotide reductase M2 polypeptide
	thymidylate synthase	92	a-,g-	15297069	thymidylate synthetase
	dihydrofolate reductase	141	g-,b-	15297069	dihydrofolate reductase
	dUTP pyrophosphatase	S	CCHV ORF49	4503423	dUTP pyrophosphatase
		S	SaHV-1 ORF49	14756895	dUTP pyrophosphatase
	thymidine kinase	S	CCHV ORF5	11430716	thymidine kinsae 2, mitochondrial
	DNA methyltransferase	S	RaHV-1 54_21	4503351	DNA (cytosine-5-)–methyltransferase 1
Enzyme	protein kinase	29	a,b,g-	14746991	serine/threonine-protein kinase PRP4
		40	a,o	4505649	protein kinase cdc2-related PCTAIRE-2
		214	o	9994197	G protein-coupled receptor kinase 7
		S	RaHV-1 54_2	14741902	CamKI–like protein kinase
	phospholipase-like protein	328	a-	5174497	endothelial cell–derived lipase precursor
	b-1,6-N-acetylglucosaminyltransf.	S	BoHV-4 ORF3-4	11431963	glucosaminyl (N–acetyl) transferase 3
	serine protease	S	CCHV ORF47	4505577	paired basic amino acid cleaving system 4
Gene expression	transcriptional activator	74	a	5174653	ring finger protein (C3H2C3 type) 6
regulation	bZIP domain	174	a-	4504809	jun B proto–oncogene
Glycoprotein	glycoprotein OX-2-like	194	b-	730246	OX-2 membrane glycoprotein precursor
	glycoprotein OX-2-like	242	g-	730246	OX-2 membrane glycoprotein precursor
Host-virus interaction	TNFR receptor	13	HHV-5 UL144	4507571	tumor necrosis factor receptor, member 14
	virion–assoc. host shutoff factor	48	a	14738228	flap structure–specific endonuclease 1
	viral interferon regulatory factor	89	g-	4504723	interferon regulatory factor 2
		243	g-	13629153	interferon consensus seq. binding prot. 1
		S	HHV-8 vIRF-3	4505287	interferon regulatory factor 4
	G protein-coupled receptor	27	b,g-	13643500	chemokine (C–C motif) receptor 2
		248	b-	4758468	G protein–coupled receptor 50
		S	EHV-2, ORF 74	4502639	chemokine (C–C motif) receptor 5
	complement binding protein	10	g-	10835143	decay accelerating factor for complement
	viral cyclin	102	g-	14767736	cyclin D1
	viral interleukin 10	140	g-	10835141	interleukin 10
	viral interleukin 6	273	g-	10834984	interleukin 6 (interferon, β 2)
	viral interleukin 17	S	HVS-2 ORF13	4504651	interleukin 17
	vBcl-2	161	g-	4502363	BCL2–antagonist-killer 1
		259	g-	4557355	B–cell lymphoma protein 2 α
		850	MeHV-1 ORF1	11433559	BCL2-like 10 (apoptosis facilitator)
	MHC I downregulation	150	g-	8923613	hypothetical protein FLJ20668
	viral FLICE–inhibitory protein	256	g-	14731507	CASP8 and FADD–like apoptosis regulator
		S	EHV-2 E8	4505229	Fas (TNFRSF6)–associated via death domain
	CxC chemokine vIL8	531	a-	10834978	interleukin 8
	vMIP-I	225	g-	5174671	small inducible cytokine subf. A, member 26
	α chemokine	321	b-	4885589	small inducible cytokine subf. B, member 9B
	β chemokine	387	b-	5174671	small inducible cytokine subf. A, member 26
	vMIP-III	S	HHV-8 K4.1	4506829	small inducible cytokine subf. A, member 17
	signal transduction protein	316	RRV, R1	12056967	Fc fragment of IgG, receptor for (CD16)
	CARD–like apoptotic protein	355	EHV-2, E10	4502379	CARD–like apoptotic protein
	U-PAR antigen CD59	352	HVS-2, ORF15	13639271	CD59 antigen p18-20
	natural killer (NK) cell decoy pr.	S	HHV-5 UL18	5031745	major histocompatibility complex, class I, E
	colony-stimulating factor I	S	HHV-4 BARF1	4885123	CD80 antigen
	C-type lectin-like protein	S	RCMV lectin	4504883	killer cell lectin–like receptor subf. C, member 2
	semaphorin homolog	S	AIHV-1 A3	4504237	sema domain, Ig domain, GPI memb. anchor
	MHC1 heavy chain	S	RCMV R144	9665232	major histocompatibility complex, class I
Unknown	unknown	258	a-	4504883	killer cell lectin–like receptor subf. C, member 2
	Unknown	S	GaHV-1 UL45	4504883	killer cell lectin–like receptor subf. C, member 2
	Unknown	S	HHV-5 UL1	14764567	pregnancy specific beta-1glycoprotein 5
	Unknown	S	HHV-5 US21	6912468	lifeguard

HPF: homologous protein family no. S indicates singleton. HPF details can be visualised by searching VIDA by HPF number in http://www.biochem.ucl.ac.uk/bsm/virus_database/VIDA.html (Herpesviridae link).

a indicates alphaherpesvirus; b, betaherpesvirus; g, gammaherpesvirus; o, other; — only a subset of subfamily members are represented. For singletons, virus abbreviation and gene name are given: CCHV, channel catfish herpesvirus; SaHV-1, salmonid herpesvirus 1; RaHV-1, ranid herpesvirus 1; BoHV-4, bovine herpesvirus 4; HHV-8, human herpesvirus 8; EHV-2, equine herpesvirus 2; HVS-2, saimiriine herpesvirus 2; MeHV-1, meleagrid herpesvirus 1; HHV-5, human herpesvirus 5; HHV-4, human herpesvirus 4; RCMV, rat cytomegalovirus; AHIV-1, alcelaphine herpesvirus 1; and GaHV-1, gallid herpesvirus 1.

GenBank protein accession no. (GI number). Only the human that hit with the lowest E-value is shown.