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. 2002 Nov;12(11):1739–1748. doi: 10.1101/gr.334302

Table 1.

Herpesvirus-Human Homologs

Function class Viral function (VIDA) HPF1 Virus2 GenBank3 Human function
DNA replication DNA polymerase 1 a,b,g 8393995 polymerase (DNA-directed), α
293 o 15303524 polymerase (DNA directed), δ 1
helicase/primase 16 a,b,g 5523990 DNA helicase
Nucleotide repair/ uracil–DNA glycosylase 8 a,b,g 6224979 uracil–DNA glycosylase
 metabolism ribonucleotide reduct. large sub. 24 a,b,g 4506749 ribonucleotide reductase M1  polypeptide
ribonucleotide reduct. small sub. 33 a,g 4557845 ribonucleotide reductase M2  polypeptide
thymidylate synthase 92 a-,g- 15297069 thymidylate synthetase
dihydrofolate reductase 141 g-,b- 15297069 dihydrofolate reductase
dUTP pyrophosphatase S CCHV ORF49 4503423 dUTP pyrophosphatase
S SaHV-1 ORF49 14756895 dUTP pyrophosphatase
thymidine kinase S CCHV ORF5 11430716 thymidine kinsae 2, mitochondrial
DNA methyltransferase S RaHV-1 54_21 4503351 DNA (cytosine-5-)–methyltransferase 1
Enzyme protein kinase 29 a,b,g- 14746991 serine/threonine-protein kinase PRP4
40 a,o 4505649 protein kinase cdc2-related PCTAIRE-2
214 o 9994197 G protein-coupled receptor kinase 7
S RaHV-1 54_2 14741902 CamKI–like protein kinase
phospholipase-like protein 328 a- 5174497 endothelial cell–derived lipase  precursor
b-1,6-N-acetylglucosaminyltransf. S BoHV-4 ORF3-4 11431963 glucosaminyl (N–acetyl) transferase 3
serine protease S CCHV ORF47 4505577 paired basic amino acid cleaving  system 4
Gene expression transcriptional activator 74 a 5174653 ring finger protein (C3H2C3 type) 6
 regulation bZIP domain 174 a- 4504809 jun B proto–oncogene
Glycoprotein glycoprotein OX-2-like 194 b- 730246 OX-2 membrane glycoprotein  precursor
glycoprotein OX-2-like 242 g- 730246 OX-2 membrane glycoprotein  precursor
Host-virus  interaction TNFR receptor 13 HHV-5 UL144 4507571 tumor necrosis factor receptor,  member 14
virion–assoc. host shutoff factor 48 a 14738228 flap structure–specific endonuclease 1
viral interferon regulatory factor 89 g- 4504723 interferon regulatory factor 2
243 g- 13629153 interferon consensus seq. binding  prot. 1
S HHV-8 vIRF-3 4505287 interferon regulatory factor 4
G protein-coupled receptor 27 b,g- 13643500 chemokine (C–C motif) receptor 2
248 b- 4758468 G protein–coupled receptor 50
S EHV-2, ORF 74 4502639 chemokine (C–C motif) receptor 5
complement binding protein 10 g- 10835143 decay accelerating factor for  complement
viral cyclin 102 g- 14767736 cyclin D1
viral interleukin 10 140 g- 10835141 interleukin 10
viral interleukin 6 273 g- 10834984 interleukin 6 (interferon, β 2)
viral interleukin 17 S HVS-2 ORF13 4504651 interleukin 17
vBcl-2 161 g- 4502363 BCL2–antagonist-killer 1
259 g- 4557355 B–cell lymphoma protein 2 α
850 MeHV-1 ORF1 11433559 BCL2-like 10 (apoptosis facilitator)
MHC I downregulation 150 g- 8923613 hypothetical protein FLJ20668
viral FLICE–inhibitory protein 256 g- 14731507 CASP8 and FADD–like apoptosis  regulator
S EHV-2 E8 4505229 Fas (TNFRSF6)–associated via death  domain
CxC chemokine vIL8 531 a- 10834978 interleukin 8
vMIP-I 225 g- 5174671 small inducible cytokine subf. A,  member 26
α chemokine 321 b- 4885589 small inducible cytokine subf. B,  member 9B
β chemokine 387 b- 5174671 small inducible cytokine subf. A,  member 26
vMIP-III S HHV-8 K4.1 4506829 small inducible cytokine subf. A,  member 17
signal transduction protein 316 RRV, R1 12056967 Fc fragment of IgG, receptor for  (CD16)
CARD–like apoptotic protein 355 EHV-2, E10 4502379 CARD–like apoptotic protein
U-PAR antigen CD59 352 HVS-2, ORF15 13639271 CD59 antigen p18-20
natural killer (NK) cell decoy pr. S HHV-5 UL18 5031745 major histocompatibility complex,  class I, E
colony-stimulating factor I S HHV-4 BARF1 4885123 CD80 antigen
C-type lectin-like protein S RCMV lectin 4504883 killer cell lectin–like receptor subf. C,  member 2
semaphorin homolog S AIHV-1 A3 4504237 sema domain, Ig domain, GPI memb.  anchor
MHC1 heavy chain S RCMV R144 9665232 major histocompatibility complex,  class I
Unknown unknown 258 a- 4504883 killer cell lectin–like receptor subf. C,  member 2
Unknown S GaHV-1 UL45 4504883 killer cell lectin–like receptor subf. C,  member 2
Unknown S HHV-5 UL1 14764567 pregnancy specific beta-1glycoprotein 5
Unknown S HHV-5 US21 6912468 lifeguard
1

HPF: homologous protein family no. S indicates singleton. HPF details can be visualised by searching VIDA by HPF number in http://www.biochem.ucl.ac.uk/bsm/virus_database/VIDA.html (Herpesviridae link). 

2

a indicates alphaherpesvirus; b, betaherpesvirus; g, gammaherpesvirus; o, other; — only a subset of subfamily members are represented. For singletons, virus abbreviation and gene name are given: CCHV, channel catfish herpesvirus; SaHV-1, salmonid herpesvirus 1; RaHV-1, ranid herpesvirus 1; BoHV-4, bovine herpesvirus 4; HHV-8, human herpesvirus 8; EHV-2, equine herpesvirus 2; HVS-2, saimiriine herpesvirus 2; MeHV-1, meleagrid herpesvirus 1; HHV-5, human herpesvirus 5; HHV-4, human herpesvirus 4; RCMV, rat cytomegalovirus; AHIV-1, alcelaphine herpesvirus 1; and GaHV-1, gallid herpesvirus 1. 

3

GenBank protein accession no. (GI number). Only the human that hit with the lowest E-value is shown.