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. 2000 Jun 6;97(12):6838–6843. doi: 10.1073/pnas.97.12.6838

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Copyright © 2000, The National Academy of Sciences

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Impact of the block of glutamate transporters on KAR-EPSCs. (A) (Left ) THA (500 μM) had no effect on rise time and early phase of decay of single KAR-EPSCs. (Right) The EPSC evoked in the presence of THA is scaled to the peak of the control trace. (B) (Left) THA (500 μM) potentiated and prolonged compound KAR-EPSCs evoked by repetitive stimulations (6 pulses, 100 Hz). (Right) Traces shown at an expanded time scale. (C) PDC (300 μM) potentiated and prolonged compound KAR-EPSCs. (D) No additional current was observed during repetitive stimulations in the presence of THA (500 μM) in GluR6^−/− mice. (E) GPT (5 units/ml) and pyruvate (2 mM) partially reversed the effect of THA (500 μM) on the decay rate of compound KAR-EPSCs evoked by repetitive stimulations. (F) GPT (5 units/ml) and pyruvate (2 mM) did not affect by itself the compound KAR-EPSCs in control conditions. All solutions contained GYKI 53655 (50 μM) or GYKI 52466 (100 μM).