Table 3.
Clinical outcomes 0–12 months
| Item | N | 0 months | 12 months | 0 months vs. 12 months | |||
| Mean (SD) | Mean (SD) | P-value | Median difference (95%-CI)* | Improved | SRM | ||
| Disease Score (0–10) | 155 | 5.95 (1.74) | 2.31 (2.29) | p < 0.001 | 4.00 (3.50 to 4.50) | 88% | 1.52 |
| Symptom Score (0–10) | 184 | 5.74 (1.81) | 3.04 (2.16) | p < 0.001 | 2.97 (2.50 to 3.25) | 83% | 1.05 |
| SF-36 scales (0–100) | |||||||
| -Physical Function | 161 | 77.09 (24.07) | 84.41 (20.69) | p < 0.001 | 7.50 (5.00 to 10.00) | 60% | 0.37 |
| -Role Physical | 157 | 55.47 (38.39) | 72.29 (36.64) | p < 0.001 | 25.00 (12.50 to 37.50) | 46% | 0.42 |
| -Role-Emotional | 157 | 68.15 (37.43) | 81.63 (31.98) | p < 0.001 | 33.33 (16.67 to 33.34) | 39% | 0.33 |
| -Social Functioning | 161 | 67.93 (25.07) | 77.10 (23.06) | p < 0.001 | 12.50 (6.25 to 18.75) | 52% | 0.34 |
| -Mental Health | 160 | 58.74 (18.25) | 66.10 (18.34) | p < 0.001 | 8.00 (4.00 to 10.00) | 63% | 0.43 |
| -Bodily Pain | 161 | 59.89 (27.62) | 71.27 (26.76) | p < 0.001 | 15.50 (9.50 to 21.00) | 54% | 0.38 |
| -Vitality | 160 | 42.53 (18.34) | 52.84 (18.49) | p < 0.001 | 12.50 (10.00 to 17.50) | 60% | 0.53 |
| -General Health | 161 | 53.10 (19.30) | 61.01 (19.48) | p < 0.001 | 8.50 (5.00 to 11.00) | 63% | 0.45 |
| SF-36 Health Change (1–5**) | 159 | 3.27 (1.08) | 2.14 (1.02) | p < 0.001 | 1.50 (1.00 to 2.00) | 65% | 0.71 |
| SF-36 Physical Component | 154 | 44.01 (10.92) | 47.99 (10.43) | p < 0.001 | 3.97 (2.71 to 5.30) | 73% | 0.42 |
| SF-36 Mental Component | 154 | 42.34 (11.98) | 46.84 (10.47) | p < 0.001 | 3.98 (2.30 to 5.71) | 64% | 0.40 |
| KINDL subscales (0–100) | |||||||
| -Psychic | 16 | 69.75 (19.91) | 69.74 (21.57) | p = 0.782 | 1.13 (-4.55 to 5.68) | 56% | 0.00 |
| -Somatic | 16 | 71.18 (17.21) | 71.74 (19.88) | p = 0.520 | 2.78 (-4.16 to 8.33) | 63% | 0.03 |
| -Social | 16 | 74.30 (14.89) | 69.73 (18.78) | p = 0.292 | -4.16 (-9.72 to 3.65) | 31% | -0.26 |
| -Function | 15 | 67.42 (12.08) | 69.18 (14.45) | p = 0.367 | 2.04 (-3.41 to 6.82) | 67% | 0.20 |
| KINDL Summary Score (0–100) | 16 | 70.39 (17.67) | 69.77 (17.91) | p = 0.889 | 0.31 (-4.02 to 4.93) | 50% | -0.06 |
| KITA subscales (0–100) | |||||||
| -Psychosoma | 31 | 62.23 (19.76) | 76.44 (13.62) | p = 0.001 | 13.54 (4.17 to 21.87) | 77% | 0.62 |
| -Daily Life | 29 | 63.22 (12.40) | 67.96 (15.43) | p = 0.038 | 6.25 (0.00 to 12.50) | 55% | 0.28 |
*Positive differences indicate improvement. Improved: Percentage of patients improved from baseline. **1 = "much better now than one year ago", 5 = "much worse now than one year ago". SRM: Standardised Response Mean effect size (small: 0.20–0.49, medium: 0.50–0.79, large: ≥ 0.80).