Figure 2.
Time-dependent release of cholesterol and PC from cultured neurons in the presence of apoE3-HDL or apoE4-HDL. The kinetics of cholesterol and PC release in the presence of apoE3- or apoE4-HDL at a cholesterol concentration of 500 ng/ml were determined. Both apoE3- (○) and apoE4-HDL (●) induced cholesterol and PC release in a time-dependent manner. Data are means ± S.E. of four samples. *p < 0.001 and **p < 0.0001 vs apoE4-HDL. Six independent experiments showed similar results.