Fig. 1.

GATA6 down-regulation in tumors and glioma stem cells. (A) Relative GATA6 expression of normal and human lung adenocarcinoma tissues (Left) from two different microarray analyses of the cancer profiling database ONCOMINE. GATA6 is found to be down-regulated (red) in tumor samples as compared with control lung (blue). Similar results were found in human ovarian cancer (Right). (B) Relative GATA6 expression in tumor stem cells derived from human glioblastomas showing higher levels when cells are exposed to serum (blue) versus stem cell medium supplemented with growth factors (red). In all cases, the ONCOMINE software, according to published cancer gene expression data, plotted the bar charts.