Table 1.

Examples of miRNAs located near solid tumor susceptibility loci

Locus/marker	Chr	Mb	Tissue	Resistant strains	Susceptible strains	Distance in bp*	miRNA homolog in human cancers†
mmu-mir-30a	1	23.5				791,353	Low lung; high pancreas
mmu-mir-30c-2	1	23.5				771,919	High prostate, colon, pancreas; low breast (miR-30c)
Lscc1/D1Mit169	1	24.3	Lung	AKR/J, C57BL/6J, 129X1/SvJ	A/J, SWR/J, NIH Swiss
mmu-mir-194–1	1	185.0				169,212	Human FRA1H
mmu-mir-215	1	185.0				168,950	Human FRA1H; high lung, stomach
Scc3/D1Mit208	1	185.1	Colon	BALB/cHeA	STS/A
Sluc17/D2Mit200	2	179.5	Lung	B10.O20	O20
mmu-mir-1–1	2	180.0				597,348
mmu-mir-133a-2	2	180.0				606,679
mmu-mir-31	4	87.2				402,170	High breast
Pas9/D4Mit77	4	87.6	Lung	BALB/c	A/J
Mmtg2/D4Mit200–308	4	118.6	Mammary	FVB/Nmul-TgN	FVB/NJ
mmu-mir-30c-1	4	119.1				469,491	High prostate, colon, pancreas; low breast (miR-30c)
mmu-mir-30e	4	119.1				472,563
Mom6/D4Mit64 - Tel	4	146.7	Small intestine	AKR/J	C57BL/6J
mmu-mir-34a	4	148.0				855,896	Human CAGR, high lung, prostate, solid cancer vs. normal
Sluc4/Pas5/D11Mit15	11	69.6	Lung	B10.O20	O20
mmu-mir-324	11	69.6				63,439
mmu-mir-195	11	69.8				286,438	High lung, prostate, solid cancer vs. normal
mmu-mir-196a-1	11	95.9				20,475	High lung, prostate (miR-196–1)
Par1/Pas5a/D11Mit54	11	95.9	Lung	C57BL/6J, BALB/c, SM/J, M. spretus	A/J
mmu-mir-10a	11	96.0				31,526	High colon, lung, solid cancer vs. normal
mmu-mir-152	11	96.5				564,754	Low pancreas, solid cancer vs. normal
mmu-mir-219–1	17	32.5				719,176	Low lung
Pas2/Pas12/D17Mit34	17	33.2	Lung	C57BL/6J	A/J

miRNAs located < 1 Mb from the peak marker of susceptibility loci on Chrs 1, 2, 4, 11, 17 are shown. For a complete list, see the MUSMIRSUS Database (www.kimmelcancercenter.org/siracusa/musmirsus.htm).

*The base pairs (bp) represent the distance between a miRNA and the closest susceptibility locus.

^†Data from refs. 18, 23, and 24 (solid cancers vs. normal tissues are from tables 10, 11, and 12 in ref. 24).