Fig. 1.

In vitro sensitivity of Eμ-myc lymphomas to different HDACi. (a) Eμ-myc lymphomas were incubated with the indicated concentrations of vorinostat (Left), oxamflatin (Center), or depsipeptide (Right) for 20 h. (b) Eμ-myc, Eμ-myc/p53^−/−, and Eμ-myc/Bcl-2 lymphomas were incubated with increasing concentrations of vorinostat (Left), and Eμ-myc and Eμ-myc/p53^−/− lymphomas were treated with increasing concentrations of Etoposide (Right) for 20 h. Cell viability was assessed by trypan blue uptake. Error bars indicate ±SEM of at least three independent experiments.